Immunoglobulin variable-region gene mutational lineage tree analysis: Application to autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Immunoglobulin variable-region gene mutational lineage tree analysis: application to autoimmune diseases.
Lineage trees have frequently been drawn to illustrate diversification, via somatic hypermutation (SHM), of immunoglobulin variable-region (IGV) genes. In order to extract more information from IGV sequences, we developed a novel mathematical method for analyzing the graphical properties of IgV gene lineage trees, allowing quantification of the differences between the dynamics of SHM and antige...
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ژورنال
عنوان ژورنال: Autoimmunity Reviews
سال: 2006
ISSN: 1568-9972
DOI: 10.1016/j.autrev.2005.07.008